The Science of Keeping the Brain Healthy | Lifespan with Dr. David Sinclair #7

In this episode of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante dissect the topic of brain aging. They explore evidence suggesting that the brain ages more slowly than other parts of the body and highlight how cognitive function is impacted by aging. Different interventions aimed at preserving brain health are also discussed, including a plant-based diet, exercise, metformin, NAD boosters, and sufficient sleep.

#DavidSinclair #Longevity #BrainHealth

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Matthew LaPlante’s Social:
Twitter – https://twitter.com/mdlaplante

Timestamps:
00:00:00 Introducing Episode Seven: Aging of the Brain
00:04:39 Thanking the Sponsors
00:07:38 Ex-differentiation as a Driver of Aging
00:09:22 The Brain Ages Slowly
00:14:17 Cognitive Function and Plasticity
00:17:44 Three Longevity Pathways: mTOR, AMPK, and Sirtuins
00:23:26 Plant-based Diets and B-vitamins
00:28:32 Homocysteine, Plaque, and Vasculature
00:32:35 Fatty Acids
00:35:48 Physical Activity
00:39:14 Metformin
00:46:02 NAD Boosters
00:50:33 Increasing Blood Flow
00:53:20 Sleep
00:58:02 Overall Message: Keep your Brain Healthy
00:58:50 Next Week’s Episode and the Future of Medicine
01:01:21 Options for Subscription for Support

Links:
The cerebellum in the brain ages slowly: https://bit.ly/3JC9CLL
Neuronal cells have a lower epigenetic age: https://bit.ly/3HVZsVA
Sirt1 regulates aging in mice: https://bit.ly/3sGZPNC
Mediterranean diet and brain health: https://bit.ly/3uUpYuL
Mediterranean diet and dementia risk: https://bit.ly/34Igp7H
Aerobic exercise improves executive functioning: https://bit.ly/34Dv5oJ
Exercise and mouse models of neurodegenerative disease: https://bit.ly/3516IRn
Strength exercises elevate the expression of BDNF: https://bit.ly/3GTLqCs
Metformin enhances cognitive ability in fish: https://bit.ly/3sLtWn2
Alzheimer’s disease and metformin: https://bit.ly/3GSdTJ5
Metformin use correlates with a reduced risk of dementia: https://bit.ly/3GT0KPO
NAD boosting and Alzheimer’s disease: https://bit.ly/367C2P2
ALS, nicotinamide riboside, and pterostilbene: https://bit.ly/3Bm2VKN
Vascular aging and NAD in mice: https://bit.ly/34Uemgx
In mice, overexpressing Sirt1 in the brain extends lifespan: https://bit.ly/3HNRyh3
Sirt1 ameliorates amyotrophic lateral sclerosis in mice: https://bit.ly/3LvUWiO
Sirt1 protects against Alzheimer’s disease in mice: https://bit.ly/34KZXUe
Sirt1 and neuroprotection in a mouse model of Huntington’s disease: https://bit.ly/3BqymDJ
Sleep loss reduces lifespan in flies: https://bit.ly/3Jt6BgA
A single night of sleep deprivation increases amyloid-beta: https://bit.ly/3uSNGaU
All-cause mortality correlates with sleep duration: https://bit.ly/3rQl14f

Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair’s teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

Title Card Photo Credit: Mike Blabac – https://www.blabacphoto.com

Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.

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